Symbol
Name
ID

Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
MGI:1098211

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Decreased circulating IgG2 level	Increased circulating IgM level	Decreased circulating antibody level	Decreased specific pneumococcal antibody level	Decreased proportion of class-switched memory B cells	Increased proportion of transitional B cells	B lymphocytopenia	T lymphocytopenia	Lymphoma	Splenomegaly
Disease(s) Associated with PIK3CD
immunodeficiency 14

Mouse Phenotypes

decreased B cell proliferation

abnormal B cell differentiation

impaired hematopoiesis

increased neutrophil cell number

decreased germinal center B cell number

decreased mature B cell number

decreased B-1 B cell number

absent B-1 B cells

decreased B-1a cell number

decreased B-2 B cell number

decreased marginal zone B cell number

decreased B cell number

decreased T follicular helper cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

increased lymphocyte cell number

increased leukocyte cell number

small spleen

spleen hypoplasia

absent spleen germinal center

decreased spleen germinal center number

decreased spleen germinal center size

abnormal B cell physiology

decreased IgA level

increased IgE level

decreased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG3 level

decreased IgG level

decreased IgM level

decreased immunoglobulin level

abnormal platelet aggregation

Availability

Mouse Genotype

Pik3cd^{Gt(OST451938)Lex}/Pik3cd^{Gt(OST451938)Lex}

Pik3cd^m2Btlr/Pik3cd^m2Btlr

Pik3cd^tm1.1Bvan/Pik3cd^tm1.1Bvan

Pik3cd^tm1Jni/Pik3cd^tm1Jni

Pik3cd^tm1Tnr/Pik3cd^tm1Tnr

Pik3cd^m2Btlr/Pik3cd⁺

Pik3cd^tm2.1Tnr/Pik3cd^tm2.1Tnr
Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺ (conditional)

Pik3cd^tm2.1Tnr/Pik3cd^tm2.1Tnr
Tg(Cd4-cre)1Cwi/0 (conditional)

Pik3cd^tm2.1Tnr/Pik3cd^tm2.1Tnr
Cd19^tm1(cre)Cgn/Cd19⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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